KMID : 1134820130420020175
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Journal of the Korean Society of Food Science and Nutrition 2013 Volume.42 No. 2 p.175 ~ p.181
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Inhibitory Effects of Lentinus edodes and Rice with Lentinus edodes mycelium on Diabetes and Obesity
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Kim Hae-Seop
You Je-Heon Cho Young-Chul Lee Young-Jae Park In-Bae Park Jeong-Wook Jung Myung-A Kim Young-Suk Kim Sun-Oh
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Abstract
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This study investigated the ability of extracts from Lentinus edodes (LE) and rice with Lentinus edodes mycelium (LEM) to inhibit diabetes and obesity. Lipid accumulation significantly decreased by 78% and 74% upon treatment with 300 ¥ìg/mL of LE and LEM, respectively (p<0.01). Cholesteryl ester transfer protein (CETP) inhibition activity increased by 94% and 99% upon treatment with 300 ¥ìg/mL of LE and LEM, respectively. In order to investigate the effect of LE and LEM on diabetes, the inhibition of protein tyrosine phosphate 1B (PTP1B) activity from the LE and LEM extracts at various concentrations (1, 3, 10, 30, 100, 300 ¥ìg/mL) was assessed. PTP1B activity by treatment with 10, 30, and 100 ¥ìg/mL of LE, was inhibited at a rate of 7, 9, and 7% respectively. Also, PTP1B activity from treatment with increasing concentration of LEM led to a significant concentration-dependent inhibition of PTP1B activity (p<0.01). LE and LEM were orally administered for 28 days after a high fat diet (HFD). LE and LEM significantly reduced triglyceride, cholesterol, HDL-cholesterol and LDL-cholesterol levels. GOT and GPT were not significantly effected. These results indicate that extracts of LE and rice with LEM have potent activities useful in the treatment of obesity and diabetes mellitus.
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KEYWORD
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3T3-L1 adipocyte, PTP1B, CETP, lipid accumulation, cholesterol
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